Medical Researches
Moderately Effective
Based on 3 Researches
Vitamin C mitigates quinalphos toxicityThe effectiveness of vitamin C on quinalphos ileal toxicity: a study of histological, ultrastructural, and oxidative stress markers.
Relevant but not food poisoning
We explored how vitamin C might protect against the toxic effects of quinalphos, a common organophosphate that poses risks to health. To understand this relationship, we set up an experiment with three groups of rats. One group received pure water, while another group was subjected to doses of quinalphos. The final group was given vitamin C alongside quinalphos for ten days.
Our observations highlighted the damage caused by quinalphos in the rats' ileum, particularly in the cellular structure. We noticed disorganized microvilli, vacuoles, and abnormal cell structures, showcasing the impact of the toxin. However, when we introduced vitamin C, the results were promising for the third group, with their ileal architecture appearing more similar to healthy controls.
The findings suggest that vitamin C could help alleviate some of the damage induced by quinalphos, protecting the intestinal cells from dysfunction. While this study specifically looked at quinalphos rather than traditional food poisoning, it opens up interesting discussions about how antioxidants like vitamin C might be beneficial in broader contexts of organ toxicity.
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To explore the effects of vitamin C on food poisoning caused by Campylobacter jejuni, we conducted a study using mice specifically bred to develop a condition similar to human campylobacteriosis. Mice were treated with synthetic vitamin C in their drinking water starting four days before they were infected with the bacteria. Our goal was to see if this treatment could lessen the severity of their symptoms.
Over the course of our research, we found that the mice receiving vitamin C had lower levels of the bacteria in their intestines. They also experienced less severe inflammation and other symptoms associated with infections. Interestingly, the benefits of vitamin C extended beyond just the intestines; we noticed reduced inflammatory responses in other organs such as the liver, kidneys, and lungs.
This suggests that vitamin C could be a promising option for both preventing and treating acute campylobacteriosis. Our findings highlight the potential health benefits of this vitamin and its role in managing foodborne illnesses like those triggered by Campylobacter jejuni.
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We examined cases of rare mixed amanita poisoning, specifically involving amanita fuliginea and amanita rimosa, where patients also experienced rhabdomyolysis. This study highlights the clinical features and outcomes of four individuals affected by these toxins after consuming the mushrooms. The initial symptoms of poisoning appeared about eight days post-ingestion, indicating a significant delay that can complicate treatment options.
All four patients faced severe health challenges, including multiple organ dysfunction primarily impacting the liver, kidneys, and central nervous system. Both acute gastrointestinal injuries and rhabdomyolysis were prevalent within just three to four days after ingestion. Treatment options for these patients ranged from persistent hemofiltration to plasma exchange, and they were also administered high-dose vitamin C, glucose, and corticosteroids.
While two patients eventually recovered, the other two faced fatal outcomes due to a high intake of mushrooms and a lack of timely medical intervention. Importantly, while vitamin C was part of the treatment regimen, the study did not isolate its impact on recovery, making it difficult to determine its specific effectiveness in combating mushroom poisoning. Therefore, early intervention with emetics and supportive therapies is crucial to minimize toxic effects and promote recovery.
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